- 1 year ago
The big focus of this episode of 5Live is on the Nepal protests where at least 16 individuals have died and over 100 are injured, following government restrictions on 26 social media platforms, including WhatsApp and YouTube, for failing to register locally.
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00:00Hi there, I'm Sonu Medotra Kapoor. This is 5 Live. Over the next one hour, we'll bring you the 5 most important stories of the day.
00:08They demand your time, they are there to ignite you and also 5 stories like we always do, bring you the healthiest, happiest version of yourself as well.
00:19So lots happening across the world and here in India, let's get started.
00:22Let's start with what's happening in Nepal as we speak. Over 15 people have died this after the Nepal government decided to ban 26 social media sites.
00:33This includes WhatsApp and Instagram, even YouTube. What is this anger that's raging and importantly, what led to this ban? We'll tell you on the program.
00:43Next up, we look at the trend of microdosing, the latest buzzword when it comes to weight loss drugs.
00:50But is it just a trend or does it have the seal of the doctors? We'll discuss that on the program as we bring to you for the first time an Indian doctor who has actually taken microdosing, has actually taken these GLP-1 drugs.
01:03Then another big health news, it's taken the world by storm. Russia's cancer shot. The new hope, is it really, as we look at cancer treatment in a whole new way?
01:14Is it too early perhaps to sort of detect that? But what exactly is this drug, is this vaccine all about? We will tell you.
01:21Then also coming up on the program, it's been a spectacular super Sunday for our men with the hockey sticks. India has won the Asia Cup that also has sealed its place in the World Cup.
01:37What exactly led to it and the stars of the show will be joining us on the program.
01:40And then finally, everybody is eyeing the big Tuesday reveal. iPhone 17 is here. But is that one camera, two, three or five? What's really going on over there?
01:52We'll bring you all the details here on Five Live.
02:00All right. Imagine waking up to no WhatsApp, no Facebook, Instagram, YouTube, Pinterest, nothing.
02:09Your digital life would turn upside down, right? Well, that's exactly what happened in Nepal when the Nepal government cracked down on major social media platforms.
02:20Let's break it down for you. These visuals have been now on for a while.
02:24But what exactly led to this protest? Why has it turned so ugly?
02:29Well, it all began when the government introduced the strict new rules requiring global tech platforms to register locally.
02:35That means register in Nepal and comply with national regulations, just as India does or any other country would perhaps.
02:44Now, a one week long notice or a deadline was issued to the platforms, the big tech companies, Facebook, YouTube, WhatsApp, Meta, Relief, X, all of them to comply or else face action.
02:56They clearly did not. They failed to respond.
02:58The government then acted swiftly, banning 26 major platforms, citing national security concerns over misinformation.
03:06Now, the backlash was immediate. First, it was the turn of the journalists.
03:11On Sunday, we saw them come out in huge numbers in Kathmandu and hit the streets, accusing the state of stifling press freedom as well.
03:19And today, those are the visuals.
03:21Now, it all began at 9 o'clock in the morning. It's still going on.
03:26That's how many people this ban has actually impacted.
03:31Youth-led protests have turned violent, with at least 16 people dead, over 100 injured.
03:38Nepal is on the edge.
03:40All right, let's cut across to some breaking news coming in.
03:46More updates there from Nepal.
03:48Let's look at what exactly is it now.
03:51The death toll, remember, has been escalating very sharply just in the past few hours.
03:56Now, protests have been reported not just now in the capital city of Kathmandu,
04:02but have gone beyond that to Pokhra, to Bharatpur as well.
04:07Curfew has been extended in Pokhra, in Kathmandu, and at least 16 people, like we reported earlier,
04:13have been declared dead so far in those clashes with the police on the ground.
04:20Over 100 injured as well.
04:23Alert has been issued at the Indo-Nepal border, remember?
04:27And we share our border very closely with Nepal.
04:30On the Bihar side as well, India's armed border guard, the SSB, has been on extra vigil as well.
04:38All right.
05:02All right, let's cut across to some live voices there.
05:06Sabine Dhamla is a journalist in Kathmandu.
05:09He joins us live now.
05:11Sabine, first of all, tell us where the time is and what is the situation there?
05:17Thank you, Sanal.
05:20I have come to the office where the protest was before.
05:26Because now the curfew has been done.
05:29So it has been good to live there.
05:31Because the army has increased.
05:34But my office is close to this.
05:38If I go to the door, I can show you.
05:40Now the situation is that the death toll has increased.
05:46See, there is no shortage of people.
05:49There is no shortage of people.
05:51There is no shortage of people.
05:53I think they are increasing.
05:55They have increased.
05:56It is not the same as the Karpandu and the Raghadhani.
06:01Like Buchwal, Bhairava, Viratnagar, Ithari, which is a big city of Pukhara,
06:07all of these people are struggling.
06:11There is also a lot of people who have died.
06:18My friend of mine has told me that there is also a village in Birgans.
06:23U.V.T. or a girl who died, but it was officially a report.
06:29I will say that this is outside of the country.
06:35Whether it's Katpandu or Katpandu from Nepal,
06:39where the movement of the JNJ today is.
06:42Now, in Katpandu, there are two-three
06:45two-three questions.
07:07Sonal, first of all, I want to give you a breaking news from Nepal, which is in Prachan
07:16Ke Netrata, it has called the Prime Minister of Raja Nama.
07:22Okay, so politics is clearly building up.
07:26Yes, yes, yes.
07:28Now this is not a problem.
07:31Yes, yes.
07:32Pankaj Das is also with us, live from Nibal, but before I go to Pankaj, Dhamrachi, I want to know you,
07:37that when I don't understand this,
07:41that when all social media are blocked,
07:44so how many people, how many numbers are in one place?
07:49You have covered protests for many years, and I have covered it a lot.
07:53We know that there is no natural protest.
07:57There are very few protests that people will go out there.
08:00It's all programmed, orchestrated,
08:04it's all being recorded,
08:06it's all being recorded,
08:07it's all being recorded.
08:08So when all social media are closed,
08:10so how many people have reached one place?
08:13as long as you can do,
08:14what it may not be found,
08:16it's all being recorded in a place.
08:17clegram,
08:21some days before,
08:22there was a reddit,
08:23there was a discord,
08:24like discord,
08:25there was nothing here.
08:26So if you want it, it will not become a look-out of social media.
08:35Because there is a thing that is banned here.
08:40First of all, I will tell you that after COVID-19,
08:45there is a recession going on in Nepal.
08:48Number one, there is a regret in Yuba Pusta.
08:53Second, the corruption here.
08:56Every year, if you look at the index,
08:58it will go down.
09:00Third, the nepotism.
09:03We are talking about Nathabad and Kripabad in Hindi and Nepal.
09:08Fourth, the political leader or government official
09:13or government's authority,
09:15the U-A-O,
09:18in this situation,
09:20there is a small, big, big, big, big protest.
09:24It is in the country.
09:25Because it is in the society.
09:27So if you look at these protests,
09:29who have organized this?
09:31No, no, no.
09:32No.
09:33No one is doing nothing.
09:34One thing is,
09:36Jenji.
09:37No one has a name on Facebook,
09:39no one has a name on Facebook.
09:42We cannot do it with that.
09:44But, no one of this has a leader,
09:47no one has come out.
09:51No one can take his job.
09:53No one has been coming out.
09:54so we can speak to this person
09:59so no one organization is doing this?
10:02no no no
10:03it is not an organization
10:06one movement, one movement
10:08was on Facebook and a movement
10:10was connected and connected
10:13and connected with each problem
10:16and each problem was one of the problems
10:18and the problem was one of the problems
10:20and the questions on the government
10:22they will ask the question
10:24whether it is in the classroom
10:26whether it is in the classroom
10:28whether it is in the home
10:30whether it is in the mind
10:32whether it is in the right
10:34yes, I have understood
10:36Damla Ji, we are being made with Pankaj Das
10:38we are also connected with Nepal
10:40I want to go to Pankaj
10:42how is it that the government
10:44did not anticipate this
10:46because this kind of protest looks like
10:48it has gone out of the hands
10:50the numbers are very very overwhelming
10:52I am trying to understand
10:54did the government not anticipate this at all?
11:02alright let me fix that line with Pankaj
11:04we also have with us Suhana joining us
11:06Suhana is an eyewitness
11:08and was at the protest a little while ago
11:10Suhana I hope you can hear my voice
11:12tell me a little bit about
11:14tell me a little bit about
11:16where exactly you were
11:18and what happened there
11:20tell me the sequence of events first
11:22so usually we got
11:24the protest started at 9 am
11:26people had started already coming down
11:28by 10, 30, 11
11:30there was a good number of people
11:32of youths and I would not say
11:34it was only Gen Z
11:36this whole conversation
11:38about Gen Z
11:40I agree with you
11:42there were a lot of people
11:43all age group
11:44I myself am not a Gen Z
11:46I am 28
11:48there were a lot of friends of my age
11:49who were there
11:50and all of us showed solidarity
11:52very peacefully
11:54but what was very shocking
11:56for all of us to also understand is
11:58there is a Hotel Everest
11:59where you have a barricade
12:01during such protests
12:02there is always a barricade given
12:04by the government of Nepal
12:06during such protests
12:07and that was not in place
12:09so it was almost as though
12:11they were inviting us
12:12into the Rashtrabhavan itself
12:14you know
12:15and what I can tell you
12:16very honestly
12:17is we had
12:18there were people
12:19who were literally sitting down
12:21you know
12:22peacefully protesting
12:23talking
12:24there was music playing
12:26there was no one was violent
12:28in any way
12:29you know
12:30so this has to be very clarified
12:31hold on
12:33hold on
12:34when you say
12:35when you say no one was violent
12:36it's the opposite of what the pictures
12:38are telling us
12:39exactly
12:40exactly
12:41it's the opposite of what the pictures
12:42are telling us
12:43so what exactly happened there
12:44it was a very peaceful
12:46it started off as a very peaceful protest
12:48and like I told you
12:49given the fact that
12:50there was no barricade
12:51these are
12:52young kids also
12:53who are part of the movement
12:54and everyone was there
12:56young
12:57old
12:58millennials
12:59you know whatever names
13:00you want to call it boomers
13:01even I would say
13:02you know at that point
13:03and at no point
13:04were there any political agendas
13:06that were being pushed
13:07we were simply there
13:08for to show solidarity
13:10against corruption
13:11and the reason
13:12you know how we are all paying such high amount of taxes
13:15but none of that is being reflected into our country's policies
13:20we understand the fact that it is an old country and our policies are new
13:24but I myself am a youth who left a high paying job from another country to come back and serve
13:31and you know do what I can to my extent and there are so many such people over here
13:36and to see the fact that we are not been given that room to grow and help grow an economy in certain ways that was frustrating
13:45just pause for a minute and help me understand this because you are saying a lot of things
13:52the narrative so far is the narrative so far is that it is a gen Z protest
13:58you are saying that it is not
14:00people from across ages are there
14:01I take that
14:02the visuals are also saying it
14:03my question is what exactly are you guys protesting because what I am hearing from you goes beyond the social media bans
14:14exactly we are protesting against the corruption and how none of the government, the citizens money is being usefully you know put to policies and you know bettering the country none of it reflects in our governance
14:30so we are protesting against the poor governance of you know the youth and they are complaining about us leaving the country
14:37but they are but you need to create sustainable environment and an ecosystem where they would want to stay back and thrive as well
14:43Sohara hold on with us
14:45hold on with us because I am going to give you a very unique opportunity
14:49Gopal Jha who is an alliance partner of the current ruling government in Nepal
14:52and a member of the member secretary from Nepali Congress as well is with us on the phone line
14:59Mr. Jha thank you so much for speaking here with us on India today
15:03Before you joined in sir I spoke with some journalists
15:07I also spoke with an eyewitness
15:09and all of them seem to be saying that this is not a gen Z asking for social media access protest
15:15this is much more and beyond that
15:19how is the government reading it
15:21how come we have not heard a single statement from the Nepal government so far
15:25when 16 people have died
15:27the number only said to escalate and more than 100 injured
15:32Thank you very much for having me on your reputed channel
15:36and first of all let me say that like it's very unfortunate to have like 16 people died
15:41in the called peaceful protest of generous JNG
15:47but at the same time I would like to also mention that
15:52you cannot rule out some infiltration from other
15:56I mean the
15:58especially I would not like to blame the opposition
16:01but there are few elements like they're always trying to
16:03the fish in the muddy
16:05I mean water
16:07and this is the practice of Nepal's like movement
16:09basically for last one year you can see that
16:12even none of the I mean the called peaceful protest or the movement
16:17I mean concluded with a peaceful I mean manner
16:20so there has always been some infiltration also
16:23so basically as the cabinet the prime minister has called the cabinet
16:27but definitely the prime minister will bring
16:29there will be some official statements from the government side also
16:32but for that you have to
16:35Can you tell us so far what is happening here?
16:37What is happening here Mr. Jha?
16:39Because everybody is telling us that this is not just about social media bans anymore
16:45there seems to be pent up anger again in the youth of Nepal asking government some tough questions
16:51and how is it that you are allowing lathe charges, water cannons and tear gas shells to be used
16:58shots to be fired to the degree that 16 people have lost their lives
17:03I do agree that like that there are anger
17:07I mean especially in the generation G for I mean the social media bans
17:12I mean you can't say just it's a total bans
17:15like the Viber is working, Tiktok is working, Tiktok is working
17:19and the government just asked them and other social media platforms to just come and register
17:25and acknowledge like what government wanted them to follow
17:29because if you enter into any government in the country you need to follow the government's rule and regulation
17:34this is what the issue was
17:36but that was little bit twisted basically
17:38but still from our party side like we have been telling government like you have to just
17:43don't completely ban it but regulate it
17:47meanwhile the General Sanji I mean announced their movement for today
17:51but unfortunately it was not totally peaceful
17:55and the unfortunate incidents took place
17:58but Gopal ji, I want to know about you
18:02and just to be very very clear I am switching to Hindi over here
18:05I want to understand why this sudden change in the government stand of having to ask all the people
18:13big tech companies to enroll
18:15has this been a work in the pipeline
18:18now we all know that these things don't happen just overnight
18:21there is always a reason, there is always a push and pull that leads to it
18:25what exactly was the government thinking by banning all of them overnight
18:30businesses are going to be impacted
18:32and I agree with the protester that it's not just about social media
18:37today social media controls a lot of other factors including business and economy
18:41I do agree that it was not totally peaceful protest especially for the social media
18:48there were anger and the young generation they have anger for everything
18:54what is going on in the country like the opportunities, education and infrastructure and lots of things
19:00but the question is like since they had announced for the peaceful protest to open I mean the social media platform
19:10and even we don't know from where the violence started and who
19:15which elements enter into it as an infiltration to create the havoc in the country
19:23so that the government was forced to take action against them
19:27but again say that this is very unfortunate that the minimum 16 youth have lost their lives
19:32but I am sure like the government would live
19:35it's unfortunate that people have lost their life is not enough
19:39calling people losing their lives
19:42these are young people in your country who have died now
19:45asking for access and clashing with the government
19:48it has to be beyond unfortunate
19:50this is not the way governments can respond anymore
19:52but here is hoping that something comes out of that cabinet meeting that has been going on for a while now
19:57and here is hoping that there is better control on the ground as well
20:01thank you so much for joining us
20:03let me also cut across to Pankaj Das who is joining us from Nepal
20:06Pankaj, just explain the current situation to us
20:08the protests in the morning at 9 o'clock
20:11now it has been a night
20:13no government has not come to us
20:16and now we don't know anything about this
20:19how escalated the situation
20:21people are sitting on a protest
20:23but this protest is so violent
20:25how was this protest?
20:26The protest that was happening
20:30the protest that was happening
20:32would not happen to any local state or party
20:34or any government
20:37there was not any protest
20:39so then, this is saying, it will be good or what is happening
20:41and when the protest happened in the country
20:43was against police
20:45their feet遇 up, then this protest would been out
20:47these protest were went around
20:49but the protest was going around
20:52right after this protest
20:54This is the same.
20:55After all these situations, the whole situation has come up to death.
21:00The government has given up to the organization.
21:04After all the government has taken up to the organization,
21:07and the government has not done anything.
21:09We've never heard about this.
21:10The government has called up to the first government.
21:15The government has said that it's been called up to the government.
21:20It has been made by Pradhan Mantri.
21:24It is not a surprise, but the Pradhan Mantri has been exposed to this process.
21:32It is the way that the Bureau is guiding it.
21:37It is a protestor, it is the way that everyone is guiding it.
21:41It is the way that the R.O. is coming out, it is the way it is.
21:44It is the way it is the way it is.
21:46It is the way it is the way it is.
21:48When the government is being taken to the government,
21:51the government is being taken to the government,
21:53it is always coming out.
21:54And now it is still happening.
21:57Thank you very much for your knowledge.
21:59We are safe.
22:00We are taking all the knowledge.
22:03And just to sum it up, I think the situation is not,
22:07doesn't seem to be showing any signs of relenting at least so far.
22:11It has been going on all morning.
22:13It is evening now.
22:14We have heard nothing from the Nepal government.
22:17And let's hope things don't go beyond this.
22:20At the moment, the situation is that there are 16 people who have lost their lives.
22:25At least, we are saying so far, because the number could escalate.
22:28More than 100 people who have been injured.
22:31Again, the number likely to escalate.
22:32And the protest is only growing.
22:34It was earlier in Kathmandu, which is the capital.
22:37And now it's gone to at least five more places.
22:41Let's see where the story goes from here.
22:43And like we've been hearing, it is much more than just a social media ban.
22:46There seems to be a pent-up anger in the youth of Nepal that's leading to such violent clashes.
22:53All right, moving on to the other big story that we are tracking.
22:57WHO has now declared GLP-1 drugs essential.
23:01Now, what does that really mean?
23:03Now, this is a major health move, global health update that we've got for you.
23:07WHO has added anti-obesity drugs or GLP-1 drugs like Ozempek, Vigovi, et cetera, Munjaro, the one we find in India, to the essential medicines list.
23:16Now, this is not just a symbolic gesture or a symbolic list.
23:21This list influences health policy, drug access, and insurance decisions over 150 countries.
23:28So the question is why now?
23:30What suddenly happened, especially when there are lawsuits going against these GLP-1 drugs,
23:34where the most expensive lawsuits of our times have been filed against Ozempek?
23:39Now, this is because they believe, WHO believes, that GLP-1 medication is highly effective in managing type 2 diabetes.
23:46And also, the headline over here, obesity.
23:50They may also, the WHO went on to say, reduce cardiovascular risks as well.
23:55But the WHO also flagged big problems here.
23:58They're saying sky-high prices.
24:00These drugs are life-changing, but out of reach for most people.
24:04To fix these, it's calling for generic competition to sort of come in with generics,
24:10to lower the cost, better access in primary care,
24:13also prioritizing patients who actually need them the most.
24:16But interestingly, the WHO didn't address the rising cosmetic use of GLP-1 drugs,
24:23despite its role in sort of limited access and driving up demand as well.
24:28But that was not the only headline which seems to have captured everybody's attention.
24:32The other big news from WHO was also that the new psychic fibrosis therapy or ETI,
24:40the cutting-edge cancer immunotherapies like PD-1, they have also been put into the list,
24:46which means all these treatments are likely now to get cheaper,
24:51which is good news if you are looking at cancer drugs.
24:54But when it comes to GLP-1, this will rock a lot of boats.
24:59This will also lead to a lot of people questioning whether or not GLP-1,
25:05the future of GLP-1 is going to be across the globe.
25:08But staying with weight loss, let's take you to the other big story.
25:11The new trend that is quietly gaining traction in India's weight loss world,
25:16it's called micro-dosing.
25:19Now instead of taking the full prescribed dose,
25:22patients are now opting for smaller,
25:24micro-amounts of popular drugs like Manjaro available in India now.
25:28Now you must be wondering, what's the goal here?
25:30Is it because it's fewer side effects or smoother results?
25:33And what exactly is micro-dosing?
25:36Is it backed by science?
25:38Or this is again something that the internet has started
25:41and perhaps your doctor will say no to.
25:43Is it a smarter way to slim down or just another risky shortcut?
25:47We had all these questions.
25:49So my colleague Soyesha actually sat down with somebody who tried this.
25:55Take a look at what that experience was like.
25:59A newer buzzword in India is micro-dosing,
26:02which means taking smaller, controlled amounts of a Zempic or Manjaro.
26:07The idea is to reduce side effects while also nudging metabolism.
26:11And doctors in India are exploring this approach very cautiously.
26:18Meet Dr. Kiran, a renowned aesthetic physician.
26:21She's been micro-dosing Manjaro for the past 10 weeks
26:24and has already lost eight and a half kilos.
26:27Here's how she did it.
26:29I've been micro-dosing Manjaro.
26:31I've lost eight and a half kgs in the past 10 weeks.
26:35What does it mean to micro-dose Manjaro?
26:38Well, look, I actually lost pretty fast.
26:40I did great lifestyle.
26:42I exercised one or two hours a day.
26:45I ate lots of protein.
26:47I strength trained.
26:48I ate my supplements and I lost fast.
26:51So what did I do?
26:52I spaced my dose out to once every two weeks or so.
26:56With thousands of lawsuits piling up abroad and Manjaro now legally available in India,
27:03the big question is, are these drugs a quick fix or a risky gamble?
27:08Doctors say micro-dosing can help track how the body is responding
27:12and may even limit some of the side effects along the way.
27:15So when we use doses which are lesser than the approved doses, we call it micro-dosing.
27:24It could be using half the strength or it could be using at a more frequent dose than approved.
27:31I think micro-dosing is something that we can use to see if they will maintain their weight
27:38or remain, you know, not have any symptoms even at the lower doses
27:42and then they can be gradually taken off.
27:48According to Dr. Kheran, drugs like Ozempic, Vigowi or Manjaro may deliver fast results,
27:53but the side effects can only be minimized if they are supported with strength training and a high-protein diet.
28:00So already being on the medicine when people come off,
28:03one-third of people are able to keep their weight off,
28:05which is three times as much as when people lose weight otherwise.
28:09So there is a way to maintain your weight,
28:12but it's through lifestyle, it's through diet, it's through exercise
28:16and it's through maintaining the changes that you're able to do with the help of Manjaro.
28:22Dr. Kheran says the key lies in losing weight wisely.
28:25Although hair fall and skin sagging on the face or body can be natural consequences of weight loss,
28:31these are effective ways to prevent them and maintain skin firmness during the process.
28:36So weight loss itself causes hair fall.
28:39Weight loss itself can cause sagging of the face and sagging of the body.
28:43Separately, we have data that it's possible that the medications themselves may increase skin aging a little bit,
28:49while it also reduces your biological age.
28:52So there's some conflicting data on that.
28:57Abroad, lawsuits against Ozempic and Manjaro have crossed 2,000,
29:01but patients reporting digestive issues and even sudden vision loss in some cases,
29:05that has also raised questions over how well patients were informed of the risks.
29:10Rare side effects, and primarily being the eye complications, pancreatitis, being others.
29:20So here what we do is we do ask people about every visit, if they're getting any symptoms,
29:25we educate them about the warning signs.
29:29If they see any of those, they do consult us and we accordingly do appropriate tests
29:35to see if they're having any of those.
29:38There are rare side effects like eye issues, gastroparesis, pancreatitis.
29:47If you have symptoms of gastroparesis or pancreatitis,
29:50then we obviously immediately stop the medication and we have you screened for that.
29:56If you have eye issues, I mean, in any case, even though it's extremely rare,
30:00and it typically happens more in diabetes,
30:02we still recommend everyone should get eye screening at least once a year.
30:05For those who struggle with mood-driven eating,
30:09doctors know that it can help reduce food noise and manage emotional eating habits.
30:14Manjaro officially launched in India this year, priced at 3,500 rupees for a 2,500 mg vial,
30:24and approximately 4,300 rupees for a 5 mg vial.
30:28That translates to a monthly cost of roughly 14,000 to 17,500 rupees if you're following the prescribed treatment.
30:37While the promise of rapid weight loss may look tempting,
30:40but you have to ensure it is always under the doctor's supervision.
30:44These may appear like magic bullets, but the safest path to long-term health is a balanced lifestyle.
30:52Suisha sounds for India today.
30:56Alright, joining us next is Dr. Chandrakant Lahiriya.
30:58He's a consultant physician and a diabetologist from New Delhi.
31:01Dr. Lahiriya, thank you so much for being with us here on India today.
31:04I want to first start by asking you,
31:06is this microdosing a medical term or a medical thing at all?
31:12Or is this just a trend that has been started on the internet?
31:18So microdosing is often used in a common term for subtherapeutic dose of medicines
31:24which are given beyond the approved level of dose.
31:28However, when it comes to these weight loss drugs, GLP-1 RA,
31:33there is a dose escalation approach.
31:36They are not necessarily microdosing because these doses are approved doses
31:40as per the regulatory body.
31:42So you give these doses in an escalated manner to avoid the side effects.
31:46And we know the side effects of nausea, vomiting,
31:48and people are not able to tolerate these drugs.
31:50So there is an interesting story behind this dose escalation approach
31:54followed for GLP-1 RA.
31:56So first thing is that GLP-1 RA are not the new drug.
31:59Of course, the ones which are available in the market are new,
32:02but the first GLP-1 RA was available in 2005, nearly 20 years ago.
32:07And when the drugs in trials were started before 2005,
32:12when people were given the dose in the clinical trials,
32:15all of them were vomiting and none of them were able to control their vomiting.
32:19So an investigator came up with the idea that let's start with a smaller dose.
32:23So current dosing pattern, which is recommended, is the approved dosing pattern.
32:26It's not the micro dosing in a real sense.
32:29It's a dose escalation approach to start on the physiological benefit
32:33and then reduce the side effect.
32:35But let's say whatever it is.
32:37Dose escalation is different from micro dosing, correct?
32:41A dose escalation is a very natural process that a doctor will anyways do.
32:46They will test your tolerance level, then increase it depending on how well your body is responding to the drug.
32:52That we get.
32:53I'm trying to understand this micro dosing, which seems to be a trend on TikTok.
32:58And even the person we spoke with, Dr. Kiran, who's a dermat herself,
33:02she has actually said that she kept, she started with 2.5 every week,
33:07but she went on to decrease the frequency at which she was taking these doses.
33:14And that, according to her, is micro dosing.
33:17Is that something that's prescribed by doctors?
33:20I do not think that is legally allowed to do micro dosing for certain drugs.
33:25These drugs, which are GLP-1 RA, should be given as per approved formulae and as per recommendation.
33:32So, giving any GLP-1 RA less than the recommended dose, which is a starting dose of 0.25 mg or 2.5 mg,
33:40is not something which I would recommend.
33:42And that is not a medical or, in my opinion, even legally valid approach.
33:46And that should be done very cautiously.
33:49All right.
33:50Not a medical, you're saying even a legally valid approach to be taking these, you know, at smaller durations.
33:57Although to say that Dr. Kiran, you know, seems to be more informed since she has that background.
34:02But are you scared, sir?
34:04And we've spoken about this so many times.
34:06Are you seeing in the market right now people who have gone on Manjaro on these drugs with self-prescription
34:14and are doing these new boutique ways or new ways in which they're taking these drugs on their own?
34:22So, we need to remember that these drugs have been licensed and studied in a certain manner.
34:28We know that we start with a certain lower dose so to reduce the side effects of these drugs.
34:34But the benefits of these drugs is achieved after dose escalation.
34:38So, I do not fully understand that what purpose you are going to achieve by giving the dose which is sub-dose
34:45than even the lowest dose of this medication.
34:48Second thing is that this is not something which has been tested or there is no clinical trial done on such benefit.
34:53So, it is really difficult to say any such way.
34:56Third thing is that these drugs should be given as a medical prescription.
35:01And the medical prescription need to follow a certain recommended approved approaches.
35:06Of course, I do understand that there are certain off-label usage but off-label usage essentially means you give the same dose which is approved for a therapeutic purpose which is not actually approved for.
35:18But then you do not temper or tinker with the amount of dose being administered.
35:23So, I do not think a micro dosing for a weight loss drug or GLP-1 RA is either economically or legally a good approach.
35:31All right.
35:32So, I think that's settled then that micro dosing A of Manjaro in the technical terms should not be done.
35:39You are saying it's medically not advised, legally not permitted either.
35:43So, both should be avoided.
35:45But then let's come down to the usage of Manjaro or the usage of GLP-1 drugs all over.
35:51Dr. Lahiriya, just a year ago the story was very different when we were talking about these drugs are just about coming to India.
35:58What is the change you have seen in the past one year of how India has adopted and sort of taken in on these GLP-1 drugs?
36:10Well, so we know that India now has two GLP-1 RA which are injectable and before that there were oral GLP-1 receptor available.
36:20Now, once a drug, once a regulatory body of a country is satisfied that this drug is useful for certain population
36:27and then it can be recommended by the government.
36:29So, before the licensing and availability of two GLP-1 RA injectables, they were available in the country which were being brought by the people at their own level.
36:40And at the time, certain of the drugs were being recommended as an off-label.
36:44For example, they were recommended for diabetes but they were being used for obesity and vice versa.
36:51So, those are the, but they, even at that time, they were being administered in the same dose which is approved and given.
36:57Correct.
36:58Of course, the availability of these drugs and there are a number of people who can potentially benefit are getting benefits of these drugs which is a useful thing.
37:05This is helping reducing obesity and reducing diabetes and also…
37:09But…
37:10Also, we heard that there are pleiotropic benefits of these drugs.
37:14Pleiotropic benefits means the benefits of these drugs go beyond reducing weight or reducing diabetes but also cardiac protection and some other benefits.
37:23Yeah.
37:24We are speaking on a very important day as well, Dr. Laharia, because WHO has added GLP-1 drugs to its essential list.
37:32Now, what this means, we just broke it down for our viewers as well before you joined in, to say that this means that they have not just recognized the use of GLP-1 drugs for diabetes but also for obesity.
37:45And they are now asking for global adoption of these drugs to happen.
37:49Also, the availability of these drugs to be made at a much cheaper rate so that it can benefit more people.
37:56Now, you know, as somebody who is just watching this space very, very closely, I am looking at WHO saying, great drug, let more and more people get it.
38:07Okay.
38:08On the other hand, I am looking at lawsuits being filed where we are looking at GLP-1 causing a sudden eyesight loss, sudden blindness, suddenly you wake up and your eyesight is gone.
38:22You are looking at very, very severe symptoms in the gut.
38:27So, is WHO missing something here?
38:31Or is this the question that often comes is, is there a lobby of GLP-1 that is playing in here?
38:38Or how are we to assess the situation from a bird's eye view?
38:42So we need to remember that any medicine has side effects.
38:47So in that sense, the GLP-1 receptor agonist should be carefully selected for the right patients.
38:52If you give to the wrong patients and if you do not screen patients properly, it can result in side effect.
38:57And that's what happens.
38:58And that's why certain countries, there are lawsuits.
39:00And those lawsuits are a typical characteristic of the United States or many other countries.
39:05That does not mean GLP-1 RA are not good medication.
39:08They are very good and effective medication.
39:10When WHO puts these drugs into essential drug lists, I think it's an important milestone.
39:16One, because a number of countries, including India, have developed their national list of essential medicines.
39:23So most countries use WHO list of essential medicines to develop their national list of essential medicines.
39:29Yes.
39:30Insurance policies, health policies, all of those.
39:33And other aspects, benefits of national list of essential medicines are that once the medicine is put into that national list of essential medicine,
39:40it motivate or nudge national government to procure their supply.
39:44But also, for example, in a country like India, this drug is an essential list medicine.
39:49Then it comes under drug price control order, which will essentially help in reducing the cost of the medication.
39:55We also know one of the GLP-1 RA will go off patent in coming year.
39:59And that will also help in shaping the market and the cost of these medications.
40:03So essentially, putting in the essential medicine list will make sort of universalize the excess of these drugs.
40:10So currently, only the people who can afford these medicines are getting.
40:14But obesity is across the socioeconomic status and different group of people cannot afford.
40:19So this is definitely a right step.
40:22Final point is that any drug, it's not that once you license that drug, it is like they are in the market.
40:29The continued post-marketing surveillance for the side effects should be done and should be reported.
40:34And that will provide the data.
40:36So essentially, when we see in India that more number of people are refusing GLP-1 RA, including Bigobi and Munjaro,
40:45that essentially is an opportunity for extending the drug adverse event reporting to the Drug Control Authority.
40:52If we know the India-specific data, that will provide useful insight.
40:56Got it.
40:57Dr. Lahiriya, thank you so much for your time and joining us with all these details.
41:03This is clearly a story we have not heard the last of.
41:05We will keep coming back to you for more.
41:07But let's switch our focus now to some other sporting action coming in.
41:11India has thrashed South Korea 4-1 to be crowned as the Men's Hockey Asia Cup champions this year in 2025.
41:19Now a brace from Dilpreet Singh and a goal each from Subjit Singh.
41:25And Amit helped India sort of decimate Korea in the final.
41:28And now joining us next on Five Live, we've got the two players, the much-talked-about players from that team here live with us.
41:36Very happy to have Manpreet Singh, Indian field hockey player, also the former captain of the national hockey team here with us.
41:45Manpreet, thank you so much for speaking with us.
41:47Thank you all. Congratulations team India. Thank you ma'am.
42:35I think we can focus all over the cup.
42:37Yes.
42:39Manpreet, you have been captain.
42:41In the tournament we have seen that you have given the current captain Harbanpreet
42:45constant guidance.
42:47He was telling us how to do it and what to do.
42:49So how are these raps going under the two players?
42:53At this time, the spirit of the team,
42:56that you have won the whole tournament,
42:59you have won a tie,
43:01and you have won all the matches.
43:03You have won the whole tournament.
43:05Yes.
43:07I was saying that we are playing with Harban
43:09at the same time.
43:11Harban was also the captain of the Paris Olympics.
43:15We have experienced a lot of time.
43:19We have understood the same thing.
43:21We are mostly the players who are in our team.
43:23We are all the same.
43:25We have understood the same thing.
43:27And the same thing has helped us
43:29in this tournament.
43:31We have helped us this tournament.
43:33We have won the team with the team.
43:35We have won the team.
43:37We have won the team.
43:39In the starting place,
43:41we are not able to finish this tournament.
43:43But the tournament is growing up,
43:45the team has become the rhythm of the team.
43:47Like the tournament is growing, the rhythm of the players and the players are getting good for the field goals and the penalty goal is getting good for the final 4-1.
44:00When you talk about penalty corners, there are many mistakes.
44:03And we are with Hardik, I would like to know.
44:06Hardik is a bit of a question.
44:09And there is a different question.
44:11This is not Pakistan.
44:13If it happens, what is the whole dynamic change?
44:16I think, ma'am, every team is the same.
44:19And if it is an Asian team, if it is a world team, we see one team as a match.
44:28And if there is any opposition, we don't play a political link on it.
44:35For us, if anyone comes in front of us, we are wearing the India team jerseys.
44:42So for us, it is very important to win every match.
44:46Right.
44:47So is it your appeal to be able to do this approach in cricket?
44:50That cricketers and sports can be mixed with politics?
44:55To play with countries?
44:57Why should it be India or Pakistani?
44:59I am not an expert in this.
45:00I am not an expert in this.
45:01I am not an expert in this.
45:02I am an expert in this.
45:03I am an expert in this.
45:04But still, when I started the game, for me, what is the sport that meets the world?
45:17You always have to play together.
45:18I think sport has a sign for the brand.
45:20I want to play all the same in ми.
45:22Manpreet, what are your views?
45:25Would India or Pakistan or hockey or cricket or pickleball be anything else to play?
45:31What do you want to play in the game?
46:01Right?
46:03Yes.
46:05Manpreet, I know you are from Punjab.
46:09Hardik, I also want to know you.
46:11But Manpreet, first of all,
46:13this victory has come.
46:15Many people have boosted their morale,
46:17especially in Punjab,
46:19where the situation is very close.
46:21Punjab floods have massive devastation.
46:23We are reporting this daily news on India Today.
46:25At this time,
46:27do you want to say something about Punjab people?
46:31Yes.
46:33We have a medal,
46:35as well as volunteers,
46:37as well as NGOs,
46:39as well as officers,
46:41as well as the ground level,
46:43who are helping people,
46:47we want to dedicate this to them.
46:49Because their support is very important.
46:51And I want to say that
46:53our whole team is standing with them.
46:55and we are all in the same direction.
46:57And we are all in the same direction.
46:59We will all try to help us.
47:01Manpreet, you are also dedicating your medal
47:03to Punjab people,
47:05who are in the flood,
47:07who are in the flood.
47:09What do you want to say?
47:11Hardik, what do you want to say?
47:13I think it is true to me.
47:15Every time we have made the medal,
47:17the gold medal,
47:19I want to dedicate
47:21that the people
47:23who are in the flood,
47:25who are in the flood,
47:27who are in the flood,
47:29who are in the house,
47:31who are in the road,
47:33who are in the flood,
47:35who are in the flood.
47:37There are a lot of things happening, right?
47:39I want to say that
47:41when we were in the war,
47:43someone asked me
47:45what pressure is on you.
47:49But I think the pressure
47:51is not on us.
47:53But for me, the pressure is
47:55what is in our state.
47:57The people who don't have
47:59to sleep,
48:00the people who don't have to eat.
48:02I think the hardest movement
48:04is the hardest movement.
48:06I think that
48:08our teammates,
48:10I guess,
48:11we want to dedicate our win,
48:12our gold medals
48:14to all these people.
48:16That's lovely indeed.
48:18There is a lot of support
48:20but it is said about Punjab.
48:22You don't want any help
48:24but in that time,
48:26there is a lot of help.
48:28Manpreet,
48:30I think the last question
48:32you both want to ask.
48:34Sometimes,
48:35there is a comparison
48:36of hockey and cricket
48:37in our country.
48:38I think that
48:39there was a time
48:40when we were asked
48:41for years
48:42about the cricket
48:43and when will we come
48:44in hockey?
48:45When will we go
48:46to an international
48:47place?
48:48It's a national sport
48:49after all.
48:50Manpreet,
48:51do you think
48:52that after the win
48:53the debate
48:54is alive?
48:55Do you think
48:56that after the win
48:57the critics
48:58will be quiet?
48:59Do you think
49:00that after the win
49:01the world cup
49:02is still
49:03still?
49:04Yes,
49:05the world cup
49:06is still still
49:07but when we
49:08won the medal
49:09in Tokyo,
49:10after that,
49:11when we talked
49:12about it,
49:13when we talked
49:14about it,
49:15when we went
49:16to India,
49:17the whole country
49:18was very good.
49:19The love
49:20for hockey
49:21has increased.
49:22in the end of the day,
49:23our country
49:24is very important.
49:25That's true.
49:26That's true.
49:27Hardik,
49:28what do you say?
49:29I guess
49:30that's true.
49:31Hardik,
49:32what do you say?
49:33I guess
49:34the two games
49:35are very dynamic.
49:36In the world cup
49:37there are only
49:384 or 5
49:39best teams.
49:40in the world cup
49:41in the world cup
49:42there are only
49:434 or 5
49:44best teams.
49:45in the world cup
49:46in the world cup
49:47there are only
49:484 or 5
49:49best teams.
49:5012 or 12
49:51teams are good.
49:52If we are going
49:53to the world cup
49:54then they have
49:5512 or 12 teams
49:56in the world cup
49:57and then you have
49:58to win.
49:59And I think
50:00the experts
50:01are saying
50:02I guess
50:03that they
50:04had our
50:052 or 21 medal
50:06I guess
50:07that they should
50:08get rid of it.
50:09Because
50:10after winning
50:11after 40 years
50:12it was an
50:13Olympic medal
50:14and winning
50:15back to back
50:16I think
50:17that our
50:18quarterfinal
50:19it was so
50:20underrated match.
50:21And then
50:22we won
50:23the Olympic medal
50:24again
50:25after 52 years.
50:26And I guess
50:27that some people
50:28see that
50:29hockey is
50:30on that level
50:31and I just
50:32want to say
50:33that comparison
50:34is a thief of joy.
50:35So I don't want
50:36to compare
50:37anything
50:38that we are
50:39focusing on
50:40that
50:41and that
50:42we are focusing on
50:43the
50:44World Cup
50:45and
50:46the
50:47World Cup
50:48also
50:49comes our way.
50:50Good luck guys.
50:53Thank you so much.
50:54Thank you so much.
50:55Another goal for Team India.
50:56Goal number 4.
50:57Sumit does it all.
50:58Alright.
50:59Prime Minister Modi has made a big GST outreach at the NDA meeting that's going on as we speak.
51:13Sources indicate that Prime Minister's big focus on Swadeshi mantra for Navratri and Diwali has been on his mind.
51:20He also said during the meeting that say it with pride that it's Swadeshi that's the Prime Minister's message going out to the members of NDA.
51:33That meeting as we speak is underway.
51:35We were expecting the Prime Minister to speak as well to the galleries and also make a statement in front of the press.
51:42But that hasn't happened so far.
51:44But let's try and find out what more is it that the Prime Minister said.
51:49Himanshu Mishra my colleague is with us now.
51:52Himanshu,
51:53Let me give you a little bit more information about how the Prime Minister has joined GST outreach to Swadeshi.
52:00The Prime Minister Narendra Modi has addressed the NDA's MPs.
52:05He said that you should be able to join GST from 20 to 30 to 30 to 20 to 30 to 20 to 30.
52:14We want to make our word more good information and make India's message.
52:26Basically that the Prime Minister represents videos about two Sureскиеõ skills that the land has Staubanvl hits,
52:30There has been amazing agreements for government values which have changed so well as you can find them.
52:34and buy it. First of all, Pradhan Mantri Narendra Modi is campaigning for local for local
52:42so many of the British Party and NDA, now the GST reforms are taking it from Swadessi
52:48and the GST is taking the support of the GST. With that, you go there and go there
52:56and also put the production of Swadessi. In that GST reform, you have to do seminars
53:04and with that, Swadessi Mele will be promoted to make in India.
53:12You have to say that the slogan of the GST will be promoted to the GST.
53:18This is not only the GST party, but also the NDA MPs, Pradhan Mantri Narendra Modi
53:24that if you will do it, the GST will also be promoted to the GST because this is the season.
53:33Got it, got it. Thank you so much, Imanchu.
53:37That was Imanchu talking about Prime Minister's pitch to NDA members right ahead of the festive season.
53:43Now, as we draw five live to a close, let's also give you a glimpse on what the world is holding its breath for.
53:49Well, it's iPhone 17 Pro launch. It's the leaks that have intrigued iPhone users even more.
53:55Now, in this lineup, both the iPhone 17 Pro and Pro Max models are set to receive major upgrades,
54:01but that's what they promise all the time, right?
54:03Maybe will that really happen? That remains to be seen.
54:06From the camera to the chipset, there seems to be a complete review of what the iPhone actually looks like.
54:13The Pro models are expected to stick with the screen sizes and Apple that the Apple introduced last year.
54:19And this is what we have from the internet so far.
54:23Let's see what finally it is that Apple comes out with.
54:27I will be careful of what we show back in front of marketing, right?
54:29We're not just code with, of course.
54:30Next.
54:31Let's see what we have from a ninja shop, right here.
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