00:03Sometimes the body's immune system is a bit overzealous, and with some autoimmune disorders,
00:09the body can end up attacking its own cells. Well, now researchers say they have identified
00:14the switch, which may be able to eventually prevent that from happening. The discovery
00:18was made by scientists with the Swiss Federal Institute of Technology, Luzon, and they
00:22identified a specific enzyme called cyclic EMP-AMP synthase, or CGAS. It's a protein
00:29that can identify viruses that enter the body, binding to their DNA and taking it to the cell's
00:34cytoplasm, while telling the body to come take care of it. Now the researchers say they've been
00:38able to identify the off switch for CGAS, which signals the body to get rid of the enzyme in
00:44areas it's not needed. Using lab-grown cells, the researchers say they found a protein complex
00:49called CRL5-SPSB3. It allows the release of another chemical called ubiquitin, a compound
00:56which causes CGAS to disappear without attacking a cell it deems foreign, meaning CGAS will no longer
01:03be able to attack healthy cells that are no threat to the body. The researchers say next
01:07steps involve developing new therapies, which may help those who suffer from autoimmune diseases.
01:12of which the scientist will be aHEAD have a Lichel Mines.
01:13We will not be able to find a similar way to research. The statistically is a vulnerable
01:14and stillual health. It has been the same goal as a whole. And that I will not be able to
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01:18Dr.1931-Adars.
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01:18Dr.1931-Box.
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