00:00Alzheimer's research may have uncovered a key link in the disease process.
00:04Scientists identified a receptor called ERBB4 in a small group of excitatory brain neurons.
00:10These neurons showed an abnormal molecular state early in Alzheimer's-like disease.
00:15The researchers found ERBB4 activity was linked to excessive brain activity and synapse loss.
00:22It also affected astrocytes and microglia, which helped maintain the brain.
00:26When scientists removed ERBB4 in mice, several harmful changes were reduced.
00:32Amyloid plaque levels also declined, while memory and spatial cognition improved.
00:37Researchers then examined brain data from 446 people.
00:41Higher ERBB4 expression was associated with greater Alzheimer's pathology and poorer cognitive performance.
00:48The findings also point to mTOR signaling as an important pathway.
00:52Scientists say ERBB4 is not the single cause of Alzheimer's disease,
00:57but it could help connect several disease processes occurring together.
01:01Further studies are needed to determine whether this mechanism can be safely targeted in patients.
01:06Disclosure.
01:07This video contains stock footage and content created or enhanced using AI-assisted tools.
01:12So there're a lot of changes in analyzing the brain.
01:12The pecan is more of a THERE tongue.
01:12There's an excellent mandate for you.
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