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An Australian-led breakthrough could transform the way cancer is treated around the world. The landmark trial involving a personalised MRNA vaccine was found to significantly reduce the risk of death or the recurrence of melanoma. The findings have taken the lead scientists including former Australian of the Year Professor Georgina Long by surprise.

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00:04When the results came in, Professor Georgina Long and her team were stunned.
00:1042%. That number is phenomenal. We did not expect it to be that high.
00:16A 42% cut in the risk of recurrence or death for advanced melanoma,
00:22which just 15 years ago was a near-death sentence.
00:26For the first time ever, we have shown that we can give the immune system a fingerprint,
00:35a specific code, a personalised vaccine.
00:38The stuff of science fiction now in a lab,
00:42with Australian scientists spearheading the cutting-edge trial.
00:46It involves the creation of tailor-made treatments based on each patient's tumour,
00:52analysing how the cells had mutated, then using Nobel Prize winning mRNA technology
00:59to teach the immune system how to attack it.
01:02Given together with typical immunotherapy drugs, they say the vaccine is a game changer.
01:09I think we'll kind of open up the potential to use this technology for other cancers.
01:14Tony was one of more than a thousand people worldwide who took part in the trial.
01:20I want to make sure I'm doing everything I can to be here for my family.
01:25Scans this week showed he's still cancer-free.
01:29In Australia, melanoma kills one person every six hours.
01:34The skin cancer has been the focus of both Professor Long and her late research partner Richard Scoliette.
01:42People die of cancer all the time and it's heartbreaking, but it's real.
01:47And so I'm very driven to do as much as I can in the short life I have.
01:52A drive for life that's led to a breakthrough.
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