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Genes may shape your health more than you think—but they don’t tell the whole story.
A massive study reveals how the balance between inheritance and environment varies by condition.

Researchers analyzed health records from nearly 45 million Americans, including twins and siblings, to explore genetic influences, shared environments, and neighborhood factors such as air quality and socioeconomic conditions. Discover what this research suggests about genes, lifestyle, and the factors that may shape your health.

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00:04What shapes your health more, your genes or the life you live?
00:08A massive study suggests genes may have the stronger influence, but the answer changes depending on the condition.
00:16Researchers analyzed health records from nearly 45 million Americans, including more than 56,000 pairs of twins and 724,000
00:26siblings.
00:26They examined 560 common conditions across 23 medical categories, comparing inherited influences with shared environmental factors and neighborhood measures such
00:37as air quality, climate, and socioeconomic conditions.
00:42Overall, nearly 40% of the conditions showed a genetic link, while about a quarter were influenced at least partly
00:49by environmental factors.
00:51But there was no single answer for every illness.
00:54Genetic influences stood up more for many cognitive disorders, while shared environmental factors played a larger role in eye and
01:03respiratory conditions.
01:05Neighborhood factors generally had a weaker effect than genes and shared environment, though they mattered for some outcomes.
01:11Poverty was linked with a higher risk of severe obesity, and climate was relevant to illnesses such as flu and
01:18Lyme disease.
01:19The researchers also found that genetic and environmental information could help predict close to 60% of monthly health spending.
01:28But there's an important limit.
01:30The study only included people from birth through age 24, so it doesn't tell us how these patterns apply to
01:36diseases of older age.
01:38Genes may set part of the stage, but our surroundings still shape the story.
01:43Genes may set part of the stage, but our surroundings still shape the story.
01:43So when it comes to health, is the bigger question what we inherit, or the bigger question what we inherit,
01:48or the bigger question what we inherit, or the bigger question what we inherit.

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