00:00Welcome to 2-Minute Neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less.
00:04In this installment, I will discuss neuroimaging.
00:07I will cover a few of the most common types of neuroimaging, CAT scans, MRI, PET scans, and fMRI.
00:13Some neuroimaging techniques allow us to see the structure of the brain, while others allow us to look at brain
00:17activity or function.
00:19Computerized tomography, also known as computerized axial tomography, is a type of structural neuroimaging.
00:24It is usually called a CAT or CT scan.
00:26It involves taking a series of X-ray images from various locations around the head.
00:30These images can then be combined to construct an image of the brain.
00:34The resolution of CT images is not that high, but they can visualize any major structural problems with the brain,
00:38like a tumor.
00:40Magnetic resonance imaging, or MRI, involves applying a combination of magnetic fields and radiofrequency energy waves to the brain.
00:48Hydrogen atoms respond to the magnetic fields and radiofrequency pulses by emitting energy.
00:52The MRI machine receives this energy and can tell what part of the brain it came from.
00:57A computer can use that information to reconstruct an image of the brain that has high spatial resolution.
01:03Positron emission tomography, or PET scanning, is a way of imaging brain function.
01:07To do a PET scan, a patient is injected with a radioactive substance that emits positrons,
01:12which then emit gamma rays when they collide with electrons in brain tissue.
01:15These gamma rays are detected by the PET scanner.
01:18Because the radioactive substance was injected into the bloodstream,
01:21what the PET scanner is detecting is the movement of blood throughout the brain.
01:24Blood flow to an area of the brain increases when that area is active,
01:27so PET scanning creates an image that highlights the areas of the brain that are being used most while the
01:31person is in the scanner.
01:33Functional MRI, or fMRI, uses a similar approach to MRI,
01:36but focuses on the different responses oxygenated and unoxygenated blood make to magnetic fields and radiofrequency energy.
01:43fMRI uses what is called blood oxygen-level dependent contrast, or BOLD,
01:47to identify changes in blood flow in the brain,
01:50and thus to identify areas of the brain that are most active.
01:53fMRI allows one to image brain function without having to inject anything,
01:57and it provides high-resolution MRI images at the same time as it provides a functional image.
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